See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

1-Stearoyl-2-Arachidonoyl-sn-Glycerol

Cayman Chemical Item Number 10008650

SAG (CAS 65914-84-3)

1-Stearoyl-2-Arachidonoyl-sn-Glycerol (CAS 65914-84-3)

See more

Description

Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades.1 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, PKCε, and PKCδ at nM concentrations.2 Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.3

1 Bell, R.M., and Burns, D.J. Lipid activation of protein kinase C. J Biol Chem 266 4661-4664 (1991).

2 Madani, S., Hichami, A., Legrand, A., et al. Implication of acyl chain diacylglycerols in activation of different isoforms of protein kinase C. FASEB J 15 2595-2601 (2001).

3 Madani, S., Hichami, A., Charkaoui-Malki, M., et al. Diacylglycerols containing ω-3 and ω-6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem 279(2) 1176-1183 (2004).

Synonyms
  • SAG
Formal Name 1-​octadecanoyl-​2-​(5Z,​8Z,​11Z,​14Z)-​eicosatetraenoyl-​sn-​glycerol
CAS Number 65914-84-3
Molecular Formula C41H72O5
Formula Weight 645.0
Formulation A solution in methyl acetate
Purity >95%
Stability 1 year
Storage -80°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCCCCCCCCCCCCCC(=O)​OC[C@H]​(CO)​OC(=O)​CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC

Background Reading

Bell, R.M., and Burns, D.J. Lipid activation of protein kinase C. J Biol Chem 266 4661-4664 (1991).

Madani, S., Hichami, A., Charkaoui-Malki, M., et al. Diacylglycerols containing ω-3 and ω-6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem 279(2) 1176-1183 (2004).

Madani, S., Hichami, A., Legrand, A., et al. Implication of acyl chain diacylglycerols in activation of different isoforms of protein kinase C. FASEB J 15 2595-2601 (2001).
Size Price Quantity Subtotal
1 mg $11.00 $0.00
5 mg $50.00 $0.00
10 mg $88.00 $0.00
25 mg $193.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

1,2-Didecanoyl-sn-glycerol
1,2-Dioctanoyl-sn-glycerol
1,2-Dioleoyl-sn-glycerol
1-Oleoyl-2-acetyl-sn-glycerol
1-Stearoyl-2-Arachidonoyl PC
NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Exclusive
Show all 6 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?