Cayman Chemical | CAY10502

10008657 CAY10502

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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA₂ (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.¹ CAY10502 is a potent inhibitor of cPLA2α with an IC₅₀ value of 4.3 nM for the purified enzyme from human platelets.² It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC₅₀ values of 570 and 0.9 nM, respectively.²

1 Schaloske, R.H., Dennis, E.A. The phospholipase A₂ superfamily and its group numbering system. Biochem Biophys Acta 1761 1246-1259 (2006).

2 Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α J Med Chem 49, 2611-2620 (2006).

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Purchase 10008657 CAY10502

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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ordered by catalog number

·	AROS Polyclonal Antibody (aa 1-50)
·	4-hydroxy Hexenal
·	CAY10502

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