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CAY10502 Exclusive

Cayman Chemical Item Number 10008657

CAY10502

See more	Inhibitors (493) Inflammation (383)

Description

Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA₂ (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.¹ CAY10502 is a potent inhibitor of cPLA2α with an IC₅₀ value of 4.3 nM for the purified enzyme from human platelets.² It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC₅₀ values of 570 and 0.9 nM, respectively.²

1 Schaloske, R.H., and Dennis, E.A. The phospholipase A₂ superfamily and its group numbering system. Biochem Biophys Acta 1761 1246-1259 (2006).

2 Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. J Med Chem 49 2611-2620 (2006).

Formal Name	3-methylhydrogen-1-[3-(4-decyloxy phenoxy)-2-oxopropyl]indole-3,5-dicarboxylate
Molecular Formula	C₃₀H₃₇NO₇
Formula Weight	523.6
Formulation	A crystalline solid
Purity	>98%
λ_max	236, 289 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(COC1=CC=C(OCCCCCCCCCC)C=C1)CN2C3=CC=C(C(O)=O)C=C3C(C(OC)=O)=C2

Background Reading

Schaloske, R.H., and Dennis, E.A. The phospholipase A₂ superfamily and its group numbering system. Biochem Biophys Acta 1761 1246-1259 (2006).

Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. J Med Chem 49 2611-2620 (2006).

CAY10502 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$27.00		$0.00
1 mg	$51.00		$0.00
5 mg	$216.00		$0.00
10 mg	$378.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-09. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

RSC-3388

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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