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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10502 Exclusive

Cayman Chemical Item Number 10008657

CAY10502

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Description

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.1 CAY10502 is a potent inhibitor of cPLA2α with an IC50 value of 4.3 nM for the purified enzyme from human platelets.2 It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.2

1 Schaloske, R.H., and Dennis, E.A. The phospholipase A2 superfamily and its group numbering system. Biochem Biophys Acta 1761 1246-1259 (2006).

2 Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. J Med Chem 49 2611-2620 (2006).

Formal Name 3-​methylhydrogen-​1-​[3-​(4-​decyloxy phenoxy)-​2-​oxopropyl]indole-​3,​5-​dicarboxylate
Molecular Formula C30H37NO7
Formula Weight 523.6
Formulation A crystalline solid
Purity >98%
λmax 236, 289 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(COC1=CC=C(OCCCCCCCCCC)​C=C1)​CN2C3=CC=C(C(O)​=O)​C=C3C(C(OC)​=O)​=C2

Background Reading

Schaloske, R.H., and Dennis, E.A. The phospholipase A2 superfamily and its group numbering system. Biochem Biophys Acta 1761 1246-1259 (2006).

Ludwig, J., Bovens, S., Brauch, C., et al. Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α. J Med Chem 49 2611-2620 (2006).

CAY10502 is available in the following screening library:

Size Price Quantity Subtotal
500 µg $27.00 $0.00
1 mg $51.00 $0.00
5 mg $216.00 $0.00
10 mg $378.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

RSC-3388

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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