Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.1 Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat.2 The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.3 Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
1
Asset, G., Leroy, A., Bauge, E., et al. Effects of dietary maritime pine (Pinus pinaster)-seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein A-I. Br J Nutr84353-360(2000).
2
Causey, J.L. Korean pine nut fatty acids induce satiety-producing hormone release in overweight human volunteers. The 231st ACS National Meeting(2006 28 March).
3
Tamotsu, T., Tatsunori, T., Morishige, J., et al. Non-methylene-interrupted polyunsaturated fatty acids: Effective substitute for arachidonate of phosphatidylinositol. Biochem Biophys Res Commun264683-688(1999).
Formal Name
5Z,9Z,12Z-octadecatrienoic acid, ethyl ester
CAS Number
493015-74-0
Molecular Formula
C20H34O2
Formula Weight
306.5
Formulation
A solution in ethanol
Purity
>98%
Stability
1 year
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCC/C=C\C/C=C\CC/C=C\CCCC(=O)OCC
Background Reading
Asset, G., Leroy, A., Bauge, E., et al. Effects of dietary maritime pine (Pinus pinaster)-seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein A-I. Br J Nutr84353-360(2000).
Causey, J.L. Korean pine nut fatty acids induce satiety-producing hormone release in overweight human volunteers. The 231st ACS National Meeting(2006 28 March).
Liu, X., Zou, H., Widlak, P., et al. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1. J Biol Chem27413836-13840(1999).
Pinolenic Acid ethyl ester is available in the following screening
libraries: