Cayman Chemical | JP83

10008660 JP83

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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

The enzyme fatty acyl amide hydrolase (FAAH) is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.¹ JP83 is an irreversible FAAH inhibitor of the carbamate class with an IC₅₀ of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.²

1 Zhang, Y.H., Zhang, G.Y., Mollat, P., et al. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein. J Biol Chem 268 18875-18881 (1993).

2 Alexander, J.P., Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chemistry & Biology 12 1179-1187 (2005).

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Purchase 10008660 JP83

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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