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JP83

Cayman Chemical Item Number 10008660

(CAS 887264-44-0)

JP83 (CAS 887264-44-0)

See more	Eicosanoids (216) Fatty Acid Amides (45) Fatty Acids (267) Lipid Mediators (47) Neuroscience (654)

Description

The enzyme fatty acyl amide hydrolase (FAAH) is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.¹ JP83 is an irreversible FAAH inhibitor of the carbamate class with an IC₅₀ of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.²

1 Zhang, Y.H., Zhang, G.Y., Mollat, P., et al. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein. J Biol Chem 268 18875-18881 (1993).

2 Alexander, J.P., and Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol 12 1179-1187 (2005).

Formal Name	3'-carbamoyl-biphenyl-3-yl-hexylphenylcarbamate
CAS Number	887264-44-0
Molecular Formula	C₂₆H₂₈N₂O₃
Formula Weight	416.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(NCCCCCCc1ccccc1)Oc1cccc(c1)c1cccc(c1)C(=O)N

Background Reading

Zhang, Y.H., Zhang, G.Y., Mollat, P., et al. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein. J Biol Chem 268 18875-18881 (1993).

Alexander, J.P., and Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol 12 1179-1187 (2005).

JP83 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$30.00		$0.00
10 mg	$57.00		$0.00
50 mg	$240.00		$0.00
100 mg	$420.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Downloads

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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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