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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10508

Cayman Chemical Item Number 10008669

(CAS 878533-35-8)

CAY10508 (CAS 878533-35-8)

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Description

Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective CB1 receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM.1 A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.

1 Muccioli, G.G., Wouters, J., Charlier, C., et al. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. J Med Chem 49 872-882 (2006).

Formal Name 1,​3-​bis(4-​bromophenyl)-​5-​phenyl-​2,​4-​imidazolidinedione
CAS Number 878533-35-8
Molecular Formula C21H14Br2N2O2
Formula Weight 486.2
Formulation A crystalline solid
Purity >98%
λmax 248 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Brc1ccc(cc1)​N1C(=O)​C(c2ccccc2)​N(c2ccc(Br)​cc2)​C1=O

Background Reading

Muccioli, G.G., Wouters, J., Charlier, C., et al. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. J Med Chem 49 872-882 (2006).

CAY10508 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $21.00 $0.00
10 mg $40.00 $0.00
25 mg $95.00 $0.00
50 mg $168.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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