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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Propylpyrazole Triol

Cayman Chemical Item Number 10008841

PPT (CAS 263717-53-9)

Propylpyrazole Triol (CAS 263717-53-9)

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Description

Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. PPT is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.1,2 In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.3

1 Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J Med Chem 43 4934-4947 (2000).

2 Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

3 Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol 289 H2039-H2047 (2005).

Synonyms
  • PPT
Formal Name 4,​4',​4''-​(4-​propyl-​1H-​pyrazole-​1,​3,​5-​triyl)tris-​phenol
CAS Number 263717-53-9
Molecular Formula C24H22N2O3
Formula Weight 386.4
Formulation A crystalline solid
Purity >98%
λmax 255 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC=C(C=C1)​N2C(C3=CC=C(O)​C=C3)​=C(CCC)​C(C4=CC=C(O)​C=C4)​=N2

Background Reading

Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J Med Chem 43 4934-4947 (2000).

Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol 289 H2039-H2047 (2005).

Propylpyrazole Triol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
25 mg $280.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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