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2,3-bis (4-Hydroxyphenyl) Propionitrile

Cayman Chemical Item Number 10008842

DPN (CAS 1428-67-7)

2,3-bis (4-Hydroxyphenyl) Propionitrile (CAS 1428-67-7)

See more	Nuclear Receptors (86) Endocrinology (335)

Description

2,3-bis(4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor β (ERβ) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC₅₀ = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays.¹ Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ERβ.

1 Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

Synonyms	DPN
Formal Name	4-hydroxy-α-(4-hydroxyphenyl)-benzenepropanenitrile
CAS Number	1428-67-7
Molecular Formula	C₁₅H₁₃NO₂
Formula Weight	239.3
Formulation	A crystalline solid
Purity	>98%
λ_max	230, 270 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NCC(Cc1ccc(O)cc1)c1ccc(O)cc1

Background Reading

Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

2,3-bis (4-Hydroxyphenyl) Propionitrile is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$31.00		$0.00
10 mg	$59.00		$0.00
50 mg	$248.00		$0.00
100 mg	$434.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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