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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10573 Exclusive

Cayman Chemical Item Number 10008846

(CAS 853652-40-1)

CAY10573 (CAS 853652-40-1)

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Description

The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively.1 CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM).1

1 Mahindroo, N., Wang, C., Liao, C., et al. Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies. J Med Chem 49 1212-1216 (2006).

Formal Name 5-​[3-​[(6-​benzoyl-​1-​propyl-​2-​naphthalenyl)oxy]propoxy]-​1H-​indole-​1-​acetic acid
CAS Number 853652-40-1
Molecular Formula C33H33NO5
Formula Weight 521.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCc1c(OCCCOc2ccc3ccn(CC(=O)​O)​c3c2)​ccc2cc(ccc12)​C(=O)​c1ccccc1

Background Reading

Mahindroo, N., Wang, C., Liao, C., et al. Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies. J Med Chem 49 1212-1216 (2006).
Size Price Quantity Subtotal
500 µg $35.00 $0.00
1 mg $67.00 $0.00
5 mg $280.00 $0.00
10 mg $490.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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