See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

1-Linoleoyl Glycerol

Cayman Chemical Item Number 10008869

1-LG

1-Linoleoyl Glycerol

See more

Description

Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy.1,2 PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans.3 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM.4 1-LG has potential application in cholesterol lowering and antiatherogenic activity.

1 Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

2 Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol Cell Physiol 259 C697-C708 (1990).

3 Caslake, M.J., and Packard, C.J. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol 14 347-352 (2003).

4 Lee, W.S., Kim, M.J., Beck, Y., et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorg Med Chem Lett 15 3573-3575 (2005).

Synonyms
  • 1-LG
Formal Name 9Z,​12Z-​octadecadienoic acid,​ 1-​glyceryl ester
Molecular Formula C21H38O4
Formula Weight 354.5
Formulation A solution in acetonitrile
Purity >90%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCC/C=C\C/C=C\CCCCCCCC(=O)​OC[C@H]​(O)​CO

Background Reading

Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

Lee, W.S., Kim, M.J., Beck, Y., et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorg Med Chem Lett 15 3573-3575 (2005).

Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol Cell Physiol 259 C697-C708 (1990).

Caslake, M.J., and Packard, C.J. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol 14 347-352 (2003).

Show all 4 Hide all but first 3

1-Linoleoyl Glycerol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
25 mg $280.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

1-Arachidonoyl Glycerol Exclusive
2-Arachidonoyl Glycerol
2-Linoleoyl Glycerol Exclusive
Arachidonoyl-2'-Fluoroethylamide
Arachidonoyl Ethanolamide
Linoleic Acid
Linoleoyl Ethanolamide
PAF Acetylhydrolase Assay Kit
PAF Acetylhydrolase Inhibitor Screening Assay Kit
Show all 9 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?