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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

CAY10503

Cayman Chemical Item Number 10008872

CAY10503

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Description

CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase.1 CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 µM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 µM CAY10503, whereas 10 µM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the following positive cells: CD14 (monocytic marker) as well as CD11b and CD11c (granulocytic markers). Approximately 60% of HL60 cells exposed to 10 µM CAY10503 expressed these markers within 72 hours.1

1 Roberti, M., Pizzirani, D., Recanatini, M., et al. Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem 49 3012-3018 (2006).

Formal Name 4-​(4-​hydroxyphenyl)phenyl-​3,​5-​benzenediol
Molecular Formula C18H14O3
Formula Weight 278.3
Formulation A crystalline solid
Purity ≥98%
λmax 207, 291 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc(cc1)​c1ccc(cc1)​c1cc(O)​cc(O)​c1

Background Reading

Roberti, M., Pizzirani, D., Recanatini, M., et al. Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem 49 3012-3018 (2006).
Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
50 mg $735.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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