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10008907 GW 9508
(CAS 885101-89-3)
GW 9508 Workbook Links
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GPR40 and GPR120 are G protein-coupled receptors (GPCR) that are activated by medium and long-chain fatty acids. In addition, there is evidence of a link between GPR40 and the ability of fatty acids to acutely potentiate insulin secretion. GW 9508 is a small-molecule agonist of GPR40 and GPR120. Stimulation of intracellular Ca2+ mobilization by GW 9508 in human embryonic kidney (HEK) 293 cells expressing GPR40 and GPR120 was observed with EC50 values of 47 nM and 2.2 µM, respectively.1 GW9508 dose dependently potentiates glucose-stimulated insulin secretion and the KCl-mediated increase in insulin secretion in MIN6 cells.1
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1
Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br J Pharmacol 148 619-628 (2006).
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Pricing updated 2010-03-18.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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