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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

GW 9508

Cayman Chemical Item Number 10008907

(CAS 885101-89-3)

GW 9508 (CAS 885101-89-3)

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Description

GPR40 and GPR120 are G protein-coupled receptors (GPCR) that are activated by medium and long-chain fatty acids. In addition, there is evidence of a link between GPR40 and the ability of fatty acids to acutely potentiate insulin secretion. GW 9508 is a small-molecule agonist of GPR40 and GPR120. Stimulation of intracellular Ca2+ mobilization by GW 9508 in human embryonic kidney (HEK) 293 cells expressing GPR40 and GPR120 was observed with EC50 values of 47 nM and 2.2 µM, respectively.1 GW9508 dose dependently potentiates glucose-stimulated insulin secretion and the KCl-mediated increase in insulin secretion in MIN6 cells.1

1 Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br J Pharmacol 148 619-628 (2006).

Formal Name 4-​[[(3-​phenoxyphenyl)methyl]amino]-​benzenepropanoic acid
CAS Number 885101-89-3
Molecular Formula C22H21NO3
Formula Weight 347.4
Formulation A crystalline solid
Purity ≥98%
λmax 245, 297 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCc1ccc(cc1)​NCc1cccc(c1)​Oc1ccccc1

Background Reading

Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br J Pharmacol 148 619-628 (2006).

GW 9508 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $30.00 $0.00
10 mg $57.00 $0.00
50 mg $240.00 $0.00
100 mg $420.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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