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10009018 JWH 015
(CAS 155471-08-2)
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JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively.1 Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis (MS), treatment with WIN 55212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease.2 JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.3
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1
Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Current Medicinal Chemistry 6 635-664 (1999).
2
Arévalo-Martín, Á., Vela, J.M., Molina-Holgado, E., et al. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J Neurosci 23(7) 2511-2516 (2003).
3
Enrhart, J., Obregon, D., Mori, T., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. Journal of Neuroinflammation 2 29-41 (2005).
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Pricing updated 2010-03-15.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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