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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

JWH 015

Cayman Chemical Item Number 10009018

(CAS 155471-08-2)

JWH 015 (CAS 155471-08-2)

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Description

JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively.1 Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis (MS), treatment with WIN 55212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease.2 JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.3

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2 Arévalo-Martín Á, Vela, J.M., Molina-Holgado, E., et al. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J Neurosci 23(7) 2511-2516 (2003).

3 Enrhart, J., Obregon, D., Mori, T., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29-41 (2005).

Formal Name (2-​methyl-​1-​propyl-​1H-​indol-​3-​yl)-​1-​naphthalenyl-​methanone
CAS Number 155471-08-2
Molecular Formula C23H21NO
Formula Weight 327.4
Formulation A crystalline solid
Purity ≥98%
λmax 219, 320 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCn1c(C)​c(c2ccccc12)​C(=O)​c1cccc2ccccc12

JWH 015 is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $56.00 $0.00
10 mg $106.00 $0.00
25 mg $252.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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