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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
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CAY10505

Cayman Chemical Item Number 10009078

(CAS 328960-84-5)

CAY10505 (CAS 328960-84-5)

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Description

Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1

1 Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J Med Chem 49 3857-3871 (2006).

Formal Name 5-​[[5-​(4-​fluorophenyl)-​2-​furanyl]methylene]-​2,​4-​thiazolidinedione
CAS Number 328960-84-5
Molecular Formula C14H8FNO3S
Formula Weight 289.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Fc1ccc(cc1)​c1ccc(/C=C2\SC(=O)​NC/2=O)​o1

Background Reading

Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J Med Chem 49 3857-3871 (2006).
Size Price Quantity Subtotal
5 mg $29.00 $0.00
10 mg $55.00 $0.00
25 mg $131.00 $0.00
50 mg $232.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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