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CAY10505

Cayman Chemical Item Number 10009078

(CAS 328960-84-5)

CAY10505 (CAS 328960-84-5)

See more	Inhibitors (493) Cancer (606) Cell Biology (281) Immunology (181) Signal Transduction (314)

Description

Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC₅₀ = 30 nM) better than the α, β, and δ isoforms (IC₅₀ = 0.94, 20, and 20 μM, respectively).¹ Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC₅₀ = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC₅₀ = 228 nM).¹ Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.¹

1 Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J Med Chem 49 3857-3871 (2006).

Formal Name	5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CAS Number	328960-84-5
Molecular Formula	C₁₄H₈FNO₃S
Formula Weight	289.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Fc1ccc(cc1)c1ccc(/C=C2\SC(=O)NC/2=O)o1

Background Reading

Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J Med Chem 49 3857-3871 (2006).

Size	Price	Quantity	Subtotal
5 mg	$29.00		$0.00
10 mg	$55.00		$0.00
25 mg	$131.00		$0.00
50 mg	$232.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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