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Didox Exclusive

Cayman Chemical Item Number 10009081

(CAS 69839-83-4)

Didox (CAS 69839-83-4)

See more	Antioxidants (62) Apoptosis (183) Cancer (606) Oxidative Injury (258)

Description

Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.¹ It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.²

1 Turchan, J., Pocernich, C.B., Gairola, C., et al. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60 307-314 (2003).

2 Inayat, M.S., Chendil, D., Mohiuddin, M., et al. Didox (A novel ribonucleotide reductase inhibitor) Overcomes bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer Biol Ther 1(5) 539-545 (2002).

Formal Name	N-3,4-tridhydroxy-benzamide
CAS Number	69839-83-4
Molecular Formula	C₇H₇NO₄
Formula Weight	169.1
Formulation	A crystalline solid
Purity	≥98%
λ_max	209, 257, 291 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)c1ccc(O)c(O)c1

Background Reading

Turchan, J., Pocernich, C.B., Gairola, C., et al. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60 307-314 (2003).

Inayat, M.S., Chendil, D., Mohiuddin, M., et al. Didox (A novel ribonucleotide reductase inhibitor) Overcomes bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer Biol Ther 1(5) 539-545 (2002).

Size	Price	Quantity	Subtotal
1 mg	$13.00		$0.00
5 mg	$59.00		$0.00
10 mg	$104.00		$0.00
50 mg	$455.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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