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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Trimidox Exclusive

Cayman Chemical Item Number 10009083

VF 233 (CAS 95933-74-7)

Trimidox (CAS 95933-74-7)

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Description

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.1

1 Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994).

2 Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic Clin Pharmacol Toxicol 98 44-50 (2006).

Synonyms
  • VF 233
Formal Name N,​3,​4,​5-​tetrahydroxy-​benzenecarboximidamide
CAS Number 95933-74-7
Molecular Formula C7H8N2O4
Formula Weight 184.2
Formulation A crystalline solid
Purity ≥98%
λmax 214, 261 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Cl.ONC(=N)​c1cc(O)​c(O)​c(O)​c1

Background Reading

Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994).

Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic Clin Pharmacol Toxicol 98 44-50 (2006).
Size Price Quantity Subtotal
5 mg $49.00 $0.00
10 mg $93.00 $0.00
50 mg $392.00 $0.00
100 mg $686.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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