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Trimidox Exclusive

Cayman Chemical Item Number 10009083

VF 233 (CAS 95933-74-7)

Trimidox (CAS 95933-74-7)

See more	Inhibitors (493) Nucleotides (5) Apoptosis (183) Bone-Related Research (30) Cancer (606)

Description

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.¹ Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.^1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 35 µM.¹

1 Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994).

2 Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic Clin Pharmacol Toxicol 98 44-50 (2006).

Synonyms	VF 233
Formal Name	N,3,4,5-tetrahydroxy-benzenecarboximidamide
CAS Number	95933-74-7
Molecular Formula	C₇H₈N₂O₄
Formula Weight	184.2
Formulation	A crystalline solid
Purity	>98%
λ_max	214, 261 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Cl.ONC(=N)c1cc(O)c(O)c(O)c1

Background Reading

Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994).

Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic Clin Pharmacol Toxicol 98 44-50 (2006).

Size	Price	Quantity	Subtotal
5 mg	$49.00		$0.00
10 mg	$93.00		$0.00
50 mg	$392.00		$0.00
100 mg	$686.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

Trimidox (hydrochloride) Exclusive

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