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β-Gal-NONOate

Cayman Chemical Item Number 10009137

(CAS 357192-77-9)

β-Gal-NONOate (CAS 357192-77-9)

See more	NO Donors (26) Cancer (666) Nitric Oxide (101)

Description

β-Gal-NONOate is a nitric oxide (NO) donor which releases NO following activation by β-galactosidase.¹ β-Gal-NONOate is stabile in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic hydrolysis, β-Gal-NONOate decomposes with a half-life of six minutes at pH 5.6.¹ β-Gal-NONOate is cytotoxic to a number of cancer cell-lines and exhibits high bactericidal activity against E. coli transformed with the β-galactosidase gene.^1,2

1 Wu, X., Tang, X., Xian, M., et al. Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors. Tetrahedron Lett 42 3779-3782 (2001).

2 Chen, C., Shi, Y., Song, J., et al. Delivery of nitric oxide released from β-Gal-NONOate activation by β-galactosidase and its activity against Escherichia coli. Biol Pharm Bull 29(6) 1239-1241 (2006).

Formal Name	1-O-(1-pyrrolidinyl-ONN-azoxy)-β-D-glucopyranose
CAS Number	357192-77-9
Molecular Formula	C₁₀H₁₉N₃O₇
Formula Weight	293.3
Formulation	A crystalline solid
Purity	≥98%
λ_max	219, 250 nm
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@H](ON=N(N2CCCC2)=O)O[C@H](CO)[C@H](O)[C@@H]1O

Background Reading

Wu, X., Tang, X., Xian, M., et al. Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors. Tetrahedron Lett 42 3779-3782 (2001).

Chen, C., Shi, Y., Song, J., et al. Delivery of nitric oxide released from β-Gal-NONOate activation by β-galactosidase and its activity against Escherichia coli. Biol Pharm Bull 29(6) 1239-1241 (2006).

β-Gal-NONOate is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
25 mg	$753.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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