Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Valinomycin

Cayman Chemical Item Number 10009152

NSC 122023 (CAS 2001-95-8)

Valinomycin (CAS 2001-95-8)

See more	Ion Channels/Blockers (13) Cell Biology (280) Signal Transduction (314)

Description

Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore antibiotic that is isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. ¹ Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.

1 Abdalah, R., Wei, L., Francis, K., et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett 405 68-73 (2006).

Synonyms	NSC 122023
Formal Name	3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaaza-cyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecaone
CAS Number	2001-95-8
Molecular Formula	C₅₄H₉₀N₆O₁₈
Formula Weight	1111.3
Formulation	A crystalline solid
Purity	>95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(C)[C@H]1OC(=O)C(NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)C(OC(=O)C(NC(=O)C(C)OC(=O)C(NC(=O)[C@H](OC(=O)[C@@H](NC(=O)C(C)OC(=O)[C@H](NC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

Background Reading

Turchan, J., Pocernich, C.B., Gairola, C., et al. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60 307-314 (2003).

Size	Price	Quantity	Subtotal
5 mg	$15.00		$0.00
10 mg	$29.00		$0.00
25 mg	$68.00		$0.00
50 mg	$120.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

FK-506

Thiocarlide

Downloads

	Download Product Insert 117 Kb PDF
	Download Material Safety Data Sheet (MSDS) 22 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640