Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr²⁰² and phospho-Tyr²⁰⁴ of rat ERK/MAPK · Host: rabbit · Application(s): WB · Extracellular-signal regulated kinase/mitogen-activated protein kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory.^1,2,3,4 The activity of this kinase is regulated by dual phosphorylation at Thr²⁰² and Tyr²⁰⁴.³

1 Johnson, G.L., and Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 1911-1912 (2002).

2 Adams, J.P., and Sweatt, J.D. Molecular psychology: Roles for the ERK MAP kinase cascade in memory.. Annu Rev Pharmacol Toxicol 42 135-163 (2002).

3 Ahn, N.G. The MAP kinase cascade. Discovery of a new signal transduction pathway.. Mol Cell Biochem 127-128 201-209 (1993).

4 Tanoue, T.J., and Nishida, E. Molecular recognitions in the MAP kinase cascades.. Cell Signal 15 455-462 (2003).

Johnson, G.L., and Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 1911-1912 (2002).

Tanoue, T.J., and Nishida, E. Molecular recognitions in the MAP kinase cascades.. Cell Signal 15 455-462 (2003).

Adams, J.P., and Sweatt, J.D. Molecular psychology: Roles for the ERK MAP kinase cascade in memory.. Annu Rev Pharmacol Toxicol 42 135-163 (2002).

Ahn, N.G. The MAP kinase cascade. Discovery of a new signal transduction pathway.. Mol Cell Biochem 127-128 201-209 (1993).

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