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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

O-2545 (hydrochloride)

Cayman Chemical Item Number 10009195

O-2545 (hydrochloride)

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Description

Cannabinoid agonists are typically highly lipophilic compounds that require solubilization with either a surfactant agent or adherence to a water miscible substance such as albumin, Tween 80, or Emulphor. O-2545 is a potent water-soluble agonist of central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 1.5 and 0.32 nM, respectively.1 When dissolved in saline, O-2545 was highly efficacious in murine behavioral models when administered either intravenously or intracerebroventricularly.1

1 Martin, B.R., Wiley, J.L., Beletskaya, I., et al. Pharmacological characterization of novel water-soluble cannabinoids. J Pharmacol Exp Ther 318 1230-1239 (2006).

Formal Name 6a,​7,​10,​10a-​tetrahydro-​3-​[5-​(1H-​imidazol-​1-​yl)-​1,​1-​dimethylpentyl]-​6,​6,​9-​trimethyl-​6H-​dibenzo[b,​d]pyran-​1-​ol,​ monohydrochloride
Molecular Formula C26H36N2O2 · HCl
Formula Weight 445.0
Formulation A crystalline solid
Purity >98%
λmax 230, 282 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC1=CC[C@@H]​([C@@]​(C)​(C)​O2)​[C@H]​(C3=C2C=C(C(C)​(C)​CCCCN4C=CN=C4)​C=C3O)​C1.Cl

Background Reading

Martin, B.R., Wiley, J.L., Beletskaya, I., et al. Pharmacological characterization of novel water-soluble cannabinoids. J Pharmacol Exp Ther 318 1230-1239 (2006).

O-2545 (hydrochloride) is available in the following screening library:

Size Price Quantity Subtotal
500 µg $76.00 $0.00
1 mg $144.00 $0.00
5 mg $608.00 $0.00
10 mg $1,064.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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