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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)-SLV 319 Exclusive

Cayman Chemical Item Number 10009226

(CAS 362519-49-1)

(±)-SLV 319 (CAS 362519-49-1)

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Description

Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders.1 (±)-SLV 319 is the mixture of the CB1 receptor antagonist SLV 319 and its distomer, SLV 319 (+)-enantiomer. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively.1 SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands.2

1 Lange, J.H.M., Coolen, H.K.A.C., van Stuivenberg, H.H., et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J Med Chem 47(3) 627-643 (2004).

2 Lange, J.H.M., van Stuivenberg, H.H., Veerman, W., et al. Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg Med Chem Lett 15 4794-4798 (2005).

Formal Name 3-​(4-​chlorophenyl)-​N-​[(4-​chlorophenyl)sulfonyl]-​4,​5-​dihydro-​N'-​methyl-​4-​phenyl-​1H-​pyrazole-​1-​carboximidamide
CAS Number 362519-49-1
Molecular Formula C23H20Cl2N4O2S
Formula Weight 487.4
Formulation A crystalline solid
Purity >98%
λmax 204, 228, 313 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C/N=C(\NS(=O)​(=O)​c1ccc(Cl)​cc1)​/N1N=C(c2ccc(Cl)​cc2)​C(C1)​c1ccccc1

Background Reading

Lange, J.H.M., Coolen, H.K.A.C., van Stuivenberg, H.H., et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J Med Chem 47(3) 627-643 (2004).

Lange, J.H.M., van Stuivenberg, H.H., Veerman, W., et al. Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg Med Chem Lett 15 4794-4798 (2005).

(±)-SLV 319 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $86.00 $0.00
10 mg $152.00 $0.00
50 mg $665.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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