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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

HDAC1 (human recombinant)

Cayman Chemical Item Number 10009231

Histone Deacetylase 1

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Description

Source: human recombinant protein consisting of a C-terminal GST-tag expressed in baculovirus expression system · Mr: ~79.9 kDa · Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. They are also involved in mediating other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.1 HDAC1 is a Class I HDAC which is related to the yeast HDAC Rpd3.2 It is primarily localized to the nucleus with ubiquitous distribution throughout human cell lines and tissues. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.2

1 Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).

2 Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1 611-616 (2006).

Synonyms
  • Histone Deacetylase 1
Formula Weight 79.9
Formulation 50 µg in 25 mM Tris-HCl, pH 8.0, containing 130 mM sodium chloride, 0.05% Tween 20, and 10% glycerol
Purity >10% by SDS-PAGE
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).

Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1 611-616 (2006).
Size Price Quantity Subtotal
1 ea $371.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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