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10009232 HDAC3/NCOR2 (human recombinant)
Histone Deacetylase 3
HDAC3/NCOR2 (human recombinant) Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Source:
human recombinant protein consisting of a C-terminal His-tag expressed in Sf9 cells
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Mr:
~49.7 kDa
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Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. They are also involved in mediating other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein.1 HDAC3 is a Class I HDAC which is related to the yeast HDAC Rpd3.2 It is primarily localized to the nucleus with ubiquitous distribution throughout human cell lines and tissues. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.2
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1
Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Medicinal Research Reviews 26(4) 397-413 (2006).
2
Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1, 611-616 (2006).
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Purchase 10009232 HDAC3/NCOR2 (human recombinant)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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Sales Department
for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-15.
Prices are subject to change without notice.
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