Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…

Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

L-759,633

Cayman Chemical Item Number 10009280

(CAS 174627-50-0)

L-759,633 (CAS 174627-50-0)

See more	Receptor Biochemistry (344) Cannabinoids (333) Receptor Agonist (161) Endocrinology (337) Neuroscience (725) Obesity (167) Pain (151)

Description

L-759,633 is a high-affinity peripheral cannabinoid receptor (CB₂)-selective agonist with K_i values of 6.4 and 1043 nM for CB₂ and central cannabinoid (CB₁) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB₂ or CB₁ receptors with IC₅₀ values of 8.1 nM and 10 µM, respectively.¹

1 Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).

Formal Name	3-(1,1-dimethylheptyl)-6aR,7,10,10aR-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
CAS Number	174627-50-0
Molecular Formula	C₂₆H₄₀O₂
Formula Weight	384.6
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCC(C)(C)c1cc(OC)c2c(c1)OC(C)(C)C1CC=C(C)C[C@@H]21

Background Reading

Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).

L-759,633 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$24.00		$0.00
5 mg	$108.00		$0.00
10 mg	$192.00		$0.00
25 mg	$420.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Show all 4 Hide all but first 3

Downloads

	Download Product Insert 108 Kb PDF
	Download Material Safety Data Sheet (MSDS) 20 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640