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10009286 (±)14(15)-EET-SI
(±)14(15)-EET-sulfonimide; (±)14(15)-EpETrE-SI
(CAS 218461-97-3)
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Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.1 (±)14(15)-EET-SI is the methyl sulfonamide analog of (±)14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to (±)14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.1 In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.2
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1
Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. Pharmacol Res 49 515-524 (2004).
2
Chen, J., Falck, J.R., Reddy, K.M., et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem 273(44) 29254-29261 (1998).
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Pricing updated 2010-03-15.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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