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SKF-96365 (hydrochloride)

Cayman Chemical Item Number 10009312

(CAS 130495-35-1)

SKF-96365 (hydrochloride) (CAS 130495-35-1)

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Description

SKF-96365 inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels with an IC50 value of approximately 10 µM.1 It inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM.2 SKF-96365 can distinguish receptor-mediated release in platelets and neutrophils from the calcium release from internal stores. However, it does not distinguish between receptor-mediated and voltage-gated release.

1 Merritt, J.E., Armstrong, W.P., Benham, C.D., et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271 515-522 (1990).

2 Hotta, A., Kim, Y.C., Kakamura, E., et al. Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum. J Smooth Muscle Res 41(6) 313-327 (2005).

Formal Name 1-​[2-​(4-​methoxyphenyl)-​2-​[3-​(4-​methoxyphenyl)propoxy]ethyl]-​1H-​imidazole,​ monohydrochloride
CAS Number 130495-35-1
Molecular Formula C22H26N2O3 · HCl
Formula Weight 402.9
Formulation A crystalline solid
Purity ≥98%
λmax 226, 275 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(CCCOC(Cn2ccnc2)​c2ccc(OC)​cc2)​cc1

Background Reading

Hotta, A., Kim, Y.C., Kakamura, E., et al. Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum. J Smooth Muscle Res 41(6) 313-327 (2005).

Merritt, J.E., Armstrong, W.P., Benham, C.D., et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271 515-522 (1990).

SKF-96365 (hydrochloride) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $15.00 $0.00
5 mg $68.00 $0.00
10 mg $120.00 $0.00
50 mg $525.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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