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PAC-1

Cayman Chemical Item Number 10009317

Procaspase-activating Compound 1 (CAS 315183-21-2)

PAC-1 (CAS 315183-21-2)

See more	Apoptosis (183) Cancer (606)

Description

Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3.¹ PAC-1 · s effectiveness was found to be directly proportional to the procaspase-3 concentration present in cells. In cancer cells, PAC-1 had an IC₅₀ value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC₅₀ values of 3.2-8.5 µM were observed.¹

1 Putt, K.S., Chen, G.W., Pearson, J.M., et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2(10) 543-550 (2006).

Synonyms	Procaspase-activating Compound 1
Formal Name	4-(phenylmethyl)-[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide, 1-piperazineacetic acid
CAS Number	315183-21-2
Molecular Formula	C₂₃H₂₈N₄O₂
Formula Weight	392.5
Formulation	A crystalline solid
Purity	>98%
λ_max	283, 293, 328 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C=CCc1cccc(/C=N\NC(=O)CN2CCN(CC2)Cc2ccccc2)c1O

Background Reading

Putt, K.S., Chen, G.W., Pearson, J.M., et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2(10) 543-550 (2006).

PAC-1 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 mg	$87.00		$0.00
50 mg	$165.00		$0.00
100 mg	$313.00		$0.00
250 mg	$696.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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