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PAC-1

Cayman Chemical Item Number 10009317

Procaspase-activating Compound 1 (CAS 315183-21-2)

PAC-1 (CAS 315183-21-2)

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Synonyms
  • Procaspase-activating Compound 1
Formal Name 4-​(phenylmethyl)-​[[2-​hydroxy-​3-​(2-​propenyl)phenyl]methylene]hydrazide,​ 1-​piperazineacetic acid
CAS Number 315183-21-2
Molecular Formula C23H28N4O2
Formula Weight 392.5
Formulation A crystalline solid
Purity >98%
λmax 283, 293, 328 nm
Stability 2 years
Storage -20°C
Shipping Wet Ice in continental US; may vary elsewhere
SMILES C=CCc1cccc(/C=N\NC(=O)​CN2CCN(CC2)​Cc2ccccc2)​c1O

Description

Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3.1 PAC-1 · s effectiveness was found to be directly proportional to the procaspase-3 concentration present in cells. In cancer cells, PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed.1

1 Putt, K.S., Chen, G.W., Pearson, J.M., et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2(10) 543-550 (2006).

Related Articles

Putt, K.S., Chen, G.W., Pearson, J.M., et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2(10) 543-550 (2006).

PAC-1 is available in the following screening library:

Pricing updated 2010-09-09. Prices are subject to change without notice.

Pricing is for North America only. Other customers should contact a distributor in their region.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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