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Dopamine Transporter (Extracellular Loop 2) Polyclonal AntibodyCayman Chemical Item Number 10009373 DAT (Extracellular Loop 2)
Description
Antigen:
peptide from the extracellular loop 2 (EL2) region of human dopamine transporter (DAT)
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Host:
rabbit
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Application(s):
WB and IHC
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The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease, and drug abuse. Levels of DAT protein expression are altered by chronic drug administration.
Background ReadingKish, S.J., Kalasinsky, K.S., Derkach, P., et al. Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24 561-567 (2001). Wilson, J.M., Kalasinsky, K.S., Levey, A.I., et al. Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nat Med 2 699-703 (1996). Zhu, M.Y., Klimek, V., Haycock, J.W., et al. Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Methods 99 37-44 (2000). Zhu, M.Y., Klimek, V., Diley, G.E., et al. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46 1275-1286 (1999). Show all 4 Hide all but first 3 |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-02-12. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA
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Copyright 2012 Cayman Chemical Company
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