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10009396 Tryptophan Hydroxylase Polyclonal Antibody
TPH
Tryptophan Hydroxylase Polyclonal Antibody Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Antigen:
recombinant rabbit TPH
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Host:
sheep
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Application(s):
western blot and immunohistochemistry (frozen sections)
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Tryptophan hydroxylase (TPH) catalyzes the first step in the biosynthesis of serotonin and melatonin.1 Thus, expression of TPH can be used as an indicator of the localization of serotonin and melatonin in brain. In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland.2 Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis.1
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1
Martinez, A., Knappskog, P.M., Haavik, J. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosyntheis. Curr Med Chem 8 1077-1091 (2001).
2
Haycock, J.W., Kumer, S.C., Lewis, D.A., et al. A monoclonal antibody to tryptophan hydroxylase: Applications and identification of the epitope. J Neurosci Meth 114 205-212 (2002).
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Purchase 10009396 Tryptophan Hydroxylase Polyclonal Antibody
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
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To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-18.
Prices are subject to change without notice.
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