Antigen: peptide corresponding to amino acid residues from the C-terminal region of rat RSK2 · Host: rabbit · Application(s): WB · The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits.¹ Recent work suggests that RSK2 exerts a tonic regulation on G protein-coupled signalling.²

1 Hanauer, A., and Young, I.D. Coffin-Lowry syndrome: Clinical and molecular features. J Med Genet 39 705-713 (2002).

2 Sheffler, D.J., Kroeze, W.K., Garcia, B.G., et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci USA 103 4717-4722 (2006).

Hanauer, A., and Young, I.D. Coffin-Lowry syndrome: Clinical and molecular features. J Med Genet 39 705-713 (2002).

Sheffler, D.J., Kroeze, W.K., Garcia, B.G., et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci USA 103 4717-4722 (2006).