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1-Stearoyl-2-Arachidonoyl PC-d₈ Exclusive

Cayman Chemical Item Number 10009431

SAPC-d₈; 1-Stearoyl-2-Arachidonoyl Phosphatidylcholine-d₈

1-Stearoyl-2-Arachidonoyl PC-d8

See more	Mass Spectrometry (265) Phospholipids (61) Atherosclerosis (325) Inflammation (396)

Description

1-Stearoyl-2-Arachidonoyl PC-d₈ contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of SAPC by GC- or LC-mass spectrometry. Oxidation of phospholipids in low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.¹ 1-stearoyl-2-arachidonoyl-sn-Glycero-3-phosphocholine (SAPC) is one of the major phospholipid species in LDL. Upon oxidation, SAPC that been shown to induce monocyte-endothelial interactions.²

1 Milne, G.L., Seal, J.R., Havrilla, C.M., et al. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J Lipid Res 46 307-319 (2005).

2 Subbanagounder, G., Leitinger, N., Schwenke, D.C., et al. Determinants of bioactivity of oxidized phospholipids: Specific oxidized fatty acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol 20 2248-2254 (2000).

Synonyms	SAPC-d8 1-Stearoyl-2-Arachidonoyl Phosphatidylcholine-d8
Formal Name	1-ocatadeconyl-2R-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glyceryl-3-phosphorylcholine-5,6,8,9,11,12,14,15-d14
Molecular Formula	C₄₆H₇₆D₈NO₈P
Formula Weight	818.2
Formulation	A solution in ethanol
Purity	≥99% deuterated forms (d1-d8)
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [O-]P(OC[C@H](OC(CCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(OCC[N+](C)(C)C)=O

Background Reading

Subbanagounder, G., Leitinger, N., Schwenke, D.C., et al. Determinants of bioactivity of oxidized phospholipids: Specific oxidized fatty acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol 20 2248-2254 (2000).

Milne, G.L., Seal, J.R., Havrilla, C.M., et al. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J Lipid Res 46 307-319 (2005).

Size	Price	Quantity	Subtotal
50 µg	$43.00		$0.00
100 µg	$82.00		$0.00
500 µg	$344.00		$0.00
1 mg	$602.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

1,2-bis(heptanoylthio) Glycerophosphocholine

1-Stearoyl-2-Arachidonoyl PC

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Batch-specific Information

FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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1-Stearoyl-2-Arachidonoyl PC-d8 Exclusive