HDAC6 (human recombinant)

Cayman Chemical Item Number 10009465

GenBank Accession No. BC069243; Histone Deacetylase 6

Description

Source: Human recombinant full length protein with an N-terminal GST-tag expressed in Sf9 cells · M_r: ~159 kDa · HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrate. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.^1,2 Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.¹

1 Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).

2 Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1 611-616 (2006).

Synonyms

GenBank Accession No. BC069243
Histone Deacetylase 6

Formula Weight

159.0

Formulation

50 µg in 25 mM Tris-HCl, pH 8.0, containing 138 mM sodium chloride, 0.05% Tween 20, and 10% glycerol

Purity

>80%

Stability

6 months

Storage

-80°C

Shipping

Dry ice in continental US; may vary elsewhere

Background Reading

Yin, H., Gao, L., Tai, H., et al. Urinary prostaglandin F_2α is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem 282(1) 329-336 (2007).

Vierhapper, H., Jörg, J., and Waldhäusl, W. Generation of prostaglandin E₂-like radioimmunoreactive material in human plasma during storage at-20 C but not at -80 C. Prostaglandins Leukot Med 18 113-117 (1985).