|
10009466 HDAC9 (human recombinant)
GenBank Accession No. NM 178423; Histone Deacetylase 9
HDAC9 (human recombinant) Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
|
Source:
human recombinant protein consisting of amino acids 604-1,066 with a C-terminal His-tag expressed in Sf9 cells
·
Mr:
50.7 kDa
·
HDAC9 is a Class IIa HDAC which is homologous to the yeast HDAC1 and is larger in size than the other classes of HDACs.1,2 Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and N-terminal domain with no similarity to HDACs in other classes. Class II HDACs can shuttle between the nucleus and cytoplasm, suggesting possible extranuclear functions including regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play an important role in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.1,2 Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.2
|
|
1
Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Medicinal Research Reviews 26(4) 397-413 (2006).
2
Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1, 611-616 (2006).
|
Purchase 10009466 HDAC9 (human recombinant)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
|
Pricing updated 2010-03-13.
Prices are subject to change without notice.
|
|
|
|
|
