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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

20-hydroxy N-Arachidonoyl Taurine

Cayman Chemical Item Number 10009501

20-hydroxy N-Arachidonoyl Taurine

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Description

Arachidonic acid is metabolized by cytochrome P450 (CYP450) 4A ω-hydroxylase to 20-HETE, which acts as a vasoconstrictor in the kidney and brain.1 During mass spectrometry lipidomics analysis of rat brain, a series of fatty acyl amides of taurine was discovered, of which arachidonoyl taurine is a prominent member.2 20-hydroxy N-Arachidonoyl taurine is a potential CYP450 metabolite of N-arachidonoyl taurine and may activate members of the transient receptor potential (TRP) family of calcium channels.3

1 McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. Am J Physiol 277 R607-R623 (1999).

2 Cravatt, B.F., and Maxey, K.M. . (2004).

3 Saghatelian, A., McKinney, M.K., Bandell, M., et al. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45(30) 9007-9015 (2006).

Formal Name 20-​hydroxy-​2-​[(1-​oxo-​5Z,​8Z,​11Z,​14Z-​eicosatetraenyl)amino]-​ethane sulfonic acid
Molecular Formula C22H37NO5S
Formula Weight 427.6
Formulation A solution in ethanol
Purity >95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​NCCS(=O)​(=O)​O

Background Reading

Cravatt, B.F., and Maxey, K.M. . (2004).

McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. Am J Physiol 277 R607-R623 (1999).

Saghatelian, A., McKinney, M.K., Bandell, M., et al. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45(30) 9007-9015 (2006).
Size Price Quantity Subtotal
25 µg $119.00 $0.00
50 µg $226.00 $0.00
100 µg $428.00 $0.00
500 µg $1,904.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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