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PtdIns-(3,4,5)-P₃-biotin (sodium salt) Exclusive

Cayman Chemical Item Number 10009531

Phosphatidylinositol-3,4,5-triphosphate C-8-biotin (sodium salt); PIP₃-biotin

PtdIns-(3,4,5)-P3-biotin (sodium salt)

See more	Phospholipids (58) Cell Biology (281) Signal Transduction (314)

Description

The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.^1,2,3 PtdIns-(3,4,5)-P₃-biotin is an affinity probe which allows the PIP₃ to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P₃-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

1 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

2 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

3 Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21^st century'? Nat Rev Drug Discov 5 903-918 (2006).

Synonyms	Phosphatidylinositol-3,4,5-triphosphate C-8-biotin (sodium salt) PIP3-biotin
Formal Name	1-((1-octanoyl-N'-biotinoyl-1,6-diaminohexane-2R-octanoyl)phosphatidyl)inositol-3,4,5-triphosphate,tetrasodium salt
Molecular Formula	C₃₅H₆₁N₃O₂₄P₄S · 4Na
Formula Weight	1155.8
Formulation	A lyophilized powder
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OCC(COC(CCCCCCCNC(CCCC[C@H]2SC[C@@](N3[H])([H])[C@]2([H])N([H])C3=O)=O)=O)OC(CCCCCCC)=O)=O

Background Reading

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21^st century'? Nat Rev Drug Discov 5 903-918 (2006).

Size	Price	Quantity	Subtotal
10 µg	$141.00		$0.00
25 µg	$317.00		$0.00
50 µg	$564.00		$0.00
100 µg	$846.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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PtdIns-(3,4,5)-P3-biotin (sodium salt) Exclusive