Cayman Chemical | CAY10512 | Description (CAS 139141-12-1)

10009536 CAY10512

(CAS 139141-12-1)

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• See more Antioxidants; NF-κB; Alzheimer's Research; Atherosclerosis; Cancer; Diabetes; Inflammation; Oxidative Injury

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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC₅₀ value for inhibition of TNF-α-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.¹

1 Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.