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CAY10512 Exclusive

Cayman Chemical Item Number 10009536

(CAS 139141-12-1)

CAY10512 (CAS 139141-12-1)

See more	Antioxidants (62) NF-κB (27) Alzheimer's Research (44) Atherosclerosis (323) Cancer (606) Diabetes (134) Inflammation (383) Oxidative Injury (258)

Description

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC₅₀ value for inhibition of TNF-α-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.¹

1 Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).

Formal Name	1-fluoro-2-[2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number	139141-12-1
Molecular Formula	C₁₅H₁₃FO
Formula Weight	228.3
Formulation	A crystalline solid
Purity	>97%
λ_max	229, 318 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COc1ccc(cc1)\C=C/c1ccccc1F

Background Reading

Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).

CAY10512 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
10 mg	$33.00		$0.00
50 mg	$149.00		$0.00
100 mg	$264.00		$0.00
500 mg	$1,155.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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