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Calcipotriol (hydrate)

Cayman Chemical Item Number 10009599

Calcipotriene (CAS 112828-00-9)

Calcipotriol (hydrate) (CAS 112828-00-9)

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Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3).1 Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response.2 Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.3

1 Kragballe, K. Vitamin D analogues in the treatment of psoriasis. J Cell Biochem 49 46-52 (1992).

2 Johansen, C., Kragballe, K., Rasmussen, M., et al. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. Br J Dermatol 151 600-607 (2004).

3 Li, M., Hener, P., Zhang, Z., et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA 103(31) 11736-11741 (2006).

Synonyms
  • Calcipotriene
Formal Name 24-​cyclopropyl-​(1α,​3β,​5Z,​7E,​22E,​24S)-​9,​10-​secochola-​5,​7,​10(19),​22-​tetraene-​1,​3,​24-​triol,​ monohydrate
CAS Number 112828-00-9
Molecular Formula C27H40O3 · H2O
Formula Weight 412.6
Formulation A crystalline solid
Purity ≥98%
λmax 264 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1C[C@H]​(O)​C(=C)​\C(=C\C=C2\CCCC3(C)​C(CC[C@@]​\23C)​[C@H]​(C)​\C=C\[C@@H]​(O)​C2CC2)​/C1

Background Reading

Kragballe, K. Vitamin D analogues in the treatment of psoriasis. J Cell Biochem 49 46-52 (1992).

Johansen, C., Kragballe, K., Rasmussen, M., et al. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. Br J Dermatol 151 600-607 (2004).

Li, M., Hener, P., Zhang, Z., et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA 103(31) 11736-11741 (2006).
Size Price Quantity Subtotal
10 mg $51.00 $0.00
50 mg $230.00 $0.00
100 mg $408.00 $0.00
500 mg $1,785.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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