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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

COX-2 (human) Western Ready Control

Cayman Chemical Item Number 10009624

Cyclooxygenase-2; Prostaglandin H Synthase 2

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Description

Application(s): positive control for WB · Source: human recombinant N-terminal His-tagged protein expressed in Sf21 cells · Mr: 73 kDa (His-tagged), 70 kDa (native) · Cyclooxygenase-2 (COX-2) catalyzes the first step in the biosynthesis of PGs, thromboxanes, and prostacyclins: the conversion of arachidonic acid to PGH2. Recent discoveries of the induction of the COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions. 1 Thus, COX-2 has become the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development.

1 Xie, W., Chipman, J.G., Robertson, D.L., et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 88 2692-2696 (1991).

Synonyms
  • Cyclooxygenase-2
  • Prostaglandin H Synthase 2
Purity Whole cell lysate
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Xie, W., Chipman, J.G., Robertson, D.L., et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 88 2692-2696 (1991).
Size Price Quantity Subtotal
1 ea $51.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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