Cayman Chemical | Prostaglandin D Synthase (hematopoietic-type; human recombinant) Western Ready Control

10009625 Prostaglandin D Synthase (hematopoietic-type; human recombinant) Western Ready Control

Hematopoietic-PGDS; H-PGDS

• See more Western Blot; Enzymes; Prostaglandins; Proteins; Recombinant Proteins; Western Ready Control; Allergy/Asthma; Drug Discovery; Inflammation; Metabolism

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Application(s): positive control for WB · Source: human recombinant protein expressed in E. coli · M_r: 23.3 kDa · Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH₂ to produce PGD₂. PGD₂ induces sleep, regulates nociception, inhibits platelet aggregation and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace) and the hematopoietic enzyme.^1,2,3,4 Lipocalin-type PGDS is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as β-trace, which is a major protein in human cerebrospinal fluid.^3,4 Hematopoietic-PGDS is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. This enzyme, which requires glutathione for activity, belongs to the sigma-class of Glutathione-S-Transferases and is implicated in allergic and inflammatory diseases.^1,5,4

1 Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

2 Jowsey, I.R., Thomson, A.M., Flanagan, J.U., et al. Mammalian class sigma glutathione s-transferases: Catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D₂ synthases. Biochem J 359 507-516 (2001).

3 Urade, Y., Watanabe, K., Hayaishi, O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 12 257-273 (1995).

4 Kanaoka, Y., Ago, H., Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90 1085-1095 (1997).

5 Urade, Y., Fujimoto, N., Ujihara, M., et al. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. J Biol Chem 262(8) 3820-3825 (1987).

	Download Product Insert 112 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 10009625 Prostaglandin D Synthase (hematopoietic-type; human recombinant) Western Ready Control

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

Related Products