Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Purmorphamine

Cayman Chemical Item Number 10009634

(CAS 483367-10-8)

Purmorphamine (CAS 483367-10-8)

See more	Bone-Related Research (30) Stem Cell Research (23)

Description

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.^1,2 The EC₅₀ value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.¹ Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.^3,4

1 Wu, X., Ding, Q., Gray, N.S., et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc 124 14520-14521 (2002).

2 Beloti, M.M., Bellesini, L.S., and Rosa, A.L. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int 29(7) 537-541 (2005).

3 Wu, X., Walker, J., Zhang, J., et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11 1229-1238 (2004).

4 Sinha, S., and Chen, J.K. Purmorphamine activates the hedgehog pathway by targeting smoothened. Nat Chem Biol 2(1) 29-30 (2006).

Formal Name	9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
CAS Number	483367-10-8
Molecular Formula	C₃₁H₃₂N₆O₂
Formula Weight	520.6
Formulation	A crystalline solid
Purity	>98%
λ_max	221, 316 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O1CCN(CC1)c1ccc(cc1)Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1

Background Reading

Wu, X., Ding, Q., Gray, N.S., et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc 124 14520-14521 (2002).

Sinha, S., and Chen, J.K. Purmorphamine activates the hedgehog pathway by targeting smoothened. Nat Chem Biol 2(1) 29-30 (2006).

Wu, X., Walker, J., Zhang, J., et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11 1229-1238 (2004).

Beloti, M.M., Bellesini, L.S., and Rosa, A.L. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int 29(7) 537-541 (2005).

Show all 4 Hide all but first 3

Purmorphamine is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$22.00		$0.00
5 mg	$99.00		$0.00
10 mg	$176.00		$0.00
25 mg	$385.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Alendronate (sodium hydrate)

Show all 7 Hide all but first 3

Downloads

	Download Product Insert 119 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640