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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

SOTS-1 (technical grade)

Cayman Chemical Item Number 10009642

Superoxide Thermal Source; Di-(4-Carboxybenzyl)Hyponitrite (CAS 223507-96-8)

SOTS-1 (technical grade) (CAS 223507-96-8)

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Description

Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms. SOTS-1 is an azo-compound that can be thermally decomposed in aqueous solution to generate superoxide radical anion at a constant, controlled rate. More specifically, SOTS-1 thermally decomposes to form an intermediate that reacts with oxygen at the diffusion-controlled limit to generate superoxide radical anion. The decay of SOTS-1 into the intermediate follows first order kinetics, and exhibits a half-life of 4900 seconds at physiological pH and temperature.1,2 This allows for study of the effect of superoxide on biologically relevant systems in a controlled environment that closely mimics conditions in vivo.

1 Konya, K.G., Paul, T., Lin, S., et al. Laser flash photolysis studies on the first superoxide thermal source. First direct measurements of the rates of solvent-assisted 1,2-hydrogen atom shifts and a proposed new mechanism for this unusual rearrangement. J Am Chem Soc 122 7518-7527 (2000).

2 Ingold, K.U., Paul, T., Young, M.J., et al. Invention of the first azo compound to serve as a superoxide thermal source under physiological conditions: Concept, synthesis, and chemical properties. J Am Chem Soc 119 12364-12365 (1997).

Synonyms
  • Superoxide Thermal Source
  • Di-(4-Carboxybenzyl)Hyponitrite
Formal Name 4,​4'-​[azobis(oxymethylene]bis-​benzoic acid
CAS Number 223507-96-8
Molecular Formula C16H14N2O6
Formula Weight 330.3
Formulation A crystalline solid
Purity >80%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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O=C(O)​C1=CC=C(CON=NOCC2=CC=C(C(O)​=O)​C=C2)​C=C1

Background Reading

Konya, K.G., Paul, T., Lin, S., et al. Laser flash photolysis studies on the first superoxide thermal source. First direct measurements of the rates of solvent-assisted 1,2-hydrogen atom shifts and a proposed new mechanism for this unusual rearrangement. J Am Chem Soc 122 7518-7527 (2000).

Ingold, K.U., Paul, T., Young, M.J., et al. Invention of the first azo compound to serve as a superoxide thermal source under physiological conditions: Concept, synthesis, and chemical properties. J Am Chem Soc 119 12364-12365 (1997).
Size Price Quantity Subtotal
500 µg $14.00 $0.00
1 mg $27.00 $0.00
5 mg $112.00 $0.00
10 mg $196.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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