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2-thio-Acetyl MAGE

Cayman Chemical Item Number 10009651

(CAS 112014-15-0)

2-thio-Acetyl MAGE (CAS 112014-15-0)

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Description

KIAA1363 is a recently characterized 2-acetyl monoacylglyceryl ether hydrolase that is critical to the survival and proliferation of many cancer cell lines.1 2-thioacetyl MAGE is a colorimetric substrate for KIAA1363. It can readily be adapted to perform activity/inhibition studies of this new enzyme, using standard DTNB detection of the free thiol as a readout for enzymatic activity.1

1 Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol 13 1041-1050 (2006).

Formal Name S-​[2-​(hexadecyloxy)-​1-​(hydroxymethyl)ethyl]ester,​ ethanethioic acid
CAS Number 112014-15-0
Molecular Formula C21H42O3S
Formula Weight 374.6
Formulation A solution in methyl acetate
Purity ≥97%
λmax 231 nm
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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OC[C@@H]​(SC(C)​=O)​COCCCCCCCCCCCCCCCC

Background Reading

Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol 13 1041-1050 (2006).

2-thio-Acetyl MAGE is available in the following screening library:

Size Price Quantity Subtotal
1 mg $31.00 $0.00
5 mg $140.00 $0.00
10 mg $248.00 $0.00
25 mg $543.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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