Cayman Chemical | FABP4 (murine recombinant) Western Ready Control | Description • ALBP; Fatty Acid Binding Protein 4; Adipocyte-FABP; A-FABP

10009676 FABP4 (murine recombinant) Western Ready Control

ALBP; Fatty Acid Binding Protein 4; Adipocyte-FABP; A-FABP

• See below for pricing and ordering

• See analysis tools

• See more Western Blot; PPAR; Proteins; Western Ready Control; Atherosclerosis; Endocrinology; Obesity

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Application(s): positive control for WB · Source: murine recombinant hexahistidine-tagged protein expressed in E. coli · M_r: 18 kDa (His-tagged), 15 kDa (native) · Fatty acid binding protein 4 (FABP4) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.¹ Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated.¹ Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.² Studies using FABP4 gene deletion in mice indicate a dominant role for FABP4 in several chronic metabolic diseases. Therefore, inhibiting the function of FABP4 is a potential mechanism for the treatment of metabolic diseases like diabetes and atherosclerosis.^3,4

1 Zimmerman, A.W., Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).

2 Massolini, G., Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).

3 Furuhashi, M., Tuncman, G., Görgün, C.Z., et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447 959-965 (2007).

4 Boord, J.B., Maeda, K., Makowski, L., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22 1686-1691 (2002).

	Download Product Insert 89 Kb PDF
	Download Material Safety Data Sheet (MSDS) 23 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 10009676 FABP4 (murine recombinant) Western Ready Control

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-14.
Prices are subject to change without notice.

Related Products